Oncogenes and tumor-suppressor genes.

  title={Oncogenes and tumor-suppressor genes.},
  author={Teresa A. Lehman and Roger R Reddel and A M Peiifer and Elisa A Spillare and M. Edward Kaighn and Anthony Weston and Brenda I. Gerwin and Curtis C. Harris},
  journal={Environmental Health Perspectives},
  pages={133 - 134}
The functional role of oncogenes in human lung carcinogenesis has been investigated by transfer of activated oncogenes into normal cells or an immortalized bronchial epithelial cell line, BEAS-2B. Transfection of v-Ha-ras, Ki-ras, or the combination of myc and raf into BEAS-2B cells produced tumorigenic cell lines, while transfection of raf or myc alone produced nontumorigenic cell lines. In addition to studying the pathogenic role of oncogenes, we are attempting to define negative growth… CONTINUE READING


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