Oncogenes and cancer.

@article{Croce2008OncogenesAC,
  title={Oncogenes and cancer.},
  author={Carlo Maria Croce},
  journal={The New England journal of medicine},
  year={2008},
  volume={358 5},
  pages={
          502-11
        }
}
  • C. Croce
  • Published 31 January 2008
  • Biology, Medicine
  • The New England journal of medicine
This review — the first in a series concerning the biology of cancer — is a comprehensive survey of oncogenes, tumor-suppressor genes, and microRNA genes in cancer cells. Work on the recently discovered microRNA genes in malignant cells has revealed new complexities in the regulation of oncogenes and tumor-suppressor genes and new opportunities for the treatment of cancer. 
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References

SHOWING 1-10 OF 85 REFERENCES
Molecular themes in oncogenesis
TLDR
It seems likely that most malignancies arise from the collaborative effects of dominant and recessive lesions, andumeration of the number of tumor suppressor genes afflicted in any given tumor may be greater. Expand
MicroRNA signatures in human cancers
TLDR
MiRNA-expression profiling of human tumours has identified signatures associated with diagnosis, staging, progression, prognosis and response to treatment and has been exploited to identify miRNA genes that might represent downstream targets of activated oncogenic pathways, or that target protein-coding genes involved in cancer. Expand
The Role of PML in Tumor Suppression
The PML gene, involved in the t(15;17) chromosomal translocation of acute promyelocytic leukemia (APL), encodes a protein which localizes to the PML-nuclear body, a subnuclear macromolecular… Expand
ras and human tumors.
TLDR
Mutational activation of ras oncogenes is frequently encountered in human tumors, but in lung cancer, childhood lymphoblastic leukemia and possibly in myelodysplastic syndromes ras mutations may predict a poor prognosis. Expand
Molecular abnormalities in lung cancer.
  • R. Salgia, A. Skarin
  • Medicine
  • Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • 1998
TLDR
The identified molecular abnormalities in lung cancer are currently used to develop diagnostics for detecting early disease, as well as to identify targets for gene therapy, to develop novel investigational approaches to the treatment of lung cancer. Expand
RAS and leukemia: from basic mechanisms to gene-directed therapy.
  • D. Beaupre, R. Kurzrock
  • Biology, Medicine
  • Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • 1999
TLDR
An increasing body of data suggests that disruption of Ras signaling pathways, either directly through mutations or indirectly through other genetic aberrations, is important in the pathogenesis of a wide variety of cancers. Expand
Targeting the BCR-ABL tyrosine kinase in chronic myeloid leukemia.
TLDR
A landmark was the discover that chronic myeloid leukemia, probably the first type of leukemia to be recognized, in the 1840s, as a distinct entity, can be treated with chemotherapy. Expand
Complete nucleotide sequences of the T24 human bladder carcinoma oncogene and its normal homologue
DNA sequence analysis of the activated oncogene from the T24 human bladder carcinoma line and two alleles of its normal cellular progenitor (c-Ha-ras-1) indicates that the genes encompass at least… Expand
Mutations of the BRAF gene in human cancer
TLDR
BRAF somatic missense mutations in 66% of malignant melanomas and at lower frequency in a wide range of human cancers, with a single substitution (V599E) accounting for 80%. Expand
AP-1 as a regulator of cell life and death
TLDR
Interestingly, the growth-promoting activity of c-Jun is mediated by repression of tumour suppressors, as well as upregulation of positive cell cycle regulators, whereas JunB has the converse effect. Expand
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