Oncogenes and cancer.

@article{Croce2008OncogenesAC,
  title={Oncogenes and cancer.},
  author={Carlo Maria Croce},
  journal={The New England journal of medicine},
  year={2008},
  volume={358 5},
  pages={
          502-11
        }
}
  • C. Croce
  • Published 31 January 2008
  • Biology, Medicine, Chemistry
  • The New England journal of medicine
This review — the first in a series concerning the biology of cancer — is a comprehensive survey of oncogenes, tumor-suppressor genes, and microRNA genes in cancer cells. Work on the recently discovered microRNA genes in malignant cells has revealed new complexities in the regulation of oncogenes and tumor-suppressor genes and new opportunities for the treatment of cancer. 
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References

SHOWING 1-10 OF 85 REFERENCES

Molecular themes in oncogenesis

[Oncogene].

TLDR
Recently, many cellular oncogenes were identified in human cancerous cells by the DNA transfection method, some of which were found to contain sequences related with already known viral oncogenees.

MicroRNA signatures in human cancers

TLDR
MiRNA-expression profiling of human tumours has identified signatures associated with diagnosis, staging, progression, prognosis and response to treatment and has been exploited to identify miRNA genes that might represent downstream targets of activated oncogenic pathways, or that target protein-coding genes involved in cancer.

The Role of PML in Tumor Suppression

ras and human tumors.

TLDR
Mutational activation of ras oncogenes is frequently encountered in human tumors, but in lung cancer, childhood lymphoblastic leukemia and possibly in myelodysplastic syndromes ras mutations may predict a poor prognosis.

Molecular abnormalities in lung cancer.

  • R. SalgiaA. Skarin
  • Medicine, Biology
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • 1998
TLDR
The identified molecular abnormalities in lung cancer are currently used to develop diagnostics for detecting early disease, as well as to identify targets for gene therapy, to develop novel investigational approaches to the treatment of lung cancer.

Targeting the BCR-ABL tyrosine kinase in chronic myeloid leukemia.

TLDR
A landmark was the discover that chronic myeloid leukemia, probably the first type of leukemia to be recognized, in the 1840s, as a distinct entity, can be treated with chemotherapy.

Complete nucleotide sequences of the T24 human bladder carcinoma oncogene and its normal homologue

DNA sequence analysis of the activated oncogene from the T24 human bladder carcinoma line and two alleles of its normal cellular progenitor (c-Ha-ras-1) indicates that the genes encompass at least…

Mutations of the BRAF gene in human cancer

TLDR
BRAF somatic missense mutations in 66% of malignant melanomas and at lower frequency in a wide range of human cancers, with a single substitution (V599E) accounting for 80%.

AP-1 as a regulator of cell life and death

TLDR
Interestingly, the growth-promoting activity of c-Jun is mediated by repression of tumour suppressors, as well as upregulation of positive cell cycle regulators, whereas JunB has the converse effect.
...