Oncogenes: The Passport for Viral Oncolysis Through PKR Inhibition

@inproceedings{Fernandes2016OncogenesTP,
  title={Oncogenes: The Passport for Viral Oncolysis Through PKR Inhibition},
  author={Jana{\'i}na de F. Fernandes},
  booktitle={Biomarkers in cancer},
  year={2016}
}
The transforming properties of oncogenes are derived from gain-of-function mutations, shifting cell signaling from highly regulated homeostatic to an uncontrolled oncogenic state, with the contribution of the inactivating mutations in tumor suppressor genes P53 and RB, leading to tumor resistance to conventional and target-directed therapy. On the other hand, this scenario fulfills two requirements for oncolytic virus infection in tumor cells: inactivation of tumor suppressors and presence of… CONTINUE READING
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