Oncogene-triggered suppression of DNA repair leads to DNA instability in cancer

  title={Oncogene-triggered suppression of DNA repair leads to DNA instability in cancer},
  author={Julia A. Yaglom and Christopher D McFarland and Leonid A. Mirny and Michael Yu Sherman},
DNA instability is an important contributor to cancer development. Previously, defects in the chromosome segregation and excessive DNA double strand breaks due to the replication or oxidative stresses were implicated in DNA instability in cancer. Here, we demonstrate that DNA instability can directly result from the oncogene-induced senescence signaling. Expression of the activated form of Her2 oncogene, NeuT, in immortalized breast epithelial cells led to downregulation of the major DNA repair… CONTINUE READING
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