Oncogene-specific activation of tyrosine kinase networks during prostate cancer progression.

  title={Oncogene-specific activation of tyrosine kinase networks during prostate cancer progression.},
  author={Justin M. Drake and Nicholas A Graham and Tanya I Stoyanova and Amir Sedghi and Andrew S. Goldstein and Houjian Cai and Daniel A. Smith and Hong Zhang and Evangelia Komisopoulou and Jiaoti Huang and Thomas G Graeber and Owen N Witte},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={109 5},
Dominant mutations or DNA amplification of tyrosine kinases are rare among the oncogenic alterations implicated in prostate cancer. We demonstrate that castration-resistant prostate cancer (CRPC) in men exhibits increased tyrosine phosphorylation, raising the question of whether enhanced tyrosine kinase activity is observed in prostate cancer in the absence of specific tyrosine kinase mutation or DNA amplification. We generated a mouse model of prostate cancer progression using commonly… CONTINUE READING
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