Oncogene overexpression in non-small-cell lung cancer tissue prevalence and clinicopathological significance

@article{Lorenz1994OncogeneOI,
  title={Oncogene overexpression in non-small-cell lung cancer tissue prevalence and clinicopathological significance},
  author={John Lorenz and Thomas Friedberg and Rebecca Paulus and Franz Oesch and R. Ferlinz},
  journal={Journal of Molecular Medicine},
  year={1994},
  volume={72},
  pages={156-163}
}
In contrast to small-cell lung cancer, few data are available on the role of oncogene overexpression in non-small-cell lung cancers (NSCLC). To determine the prevalence and extent of the transcriptional activation of cancer genes in NSCLC we investigated the level of mRNA of the three important cellular oncogenes — erbB2, Ki-ras, and c-myc — in 39 surgically or endoscopically obtained tumor samples and 24 samples of normal bronchopulmonary tissue taken from the same patients. Tissue RNA was… CONTINUE READING
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