Oncogene-like induction of cellular invasion from centrosome amplification

@inproceedings{Godinho2014OncogenelikeIO,
  title={Oncogene-like induction of cellular invasion from centrosome amplification},
  author={Susana A Godinho and Remigio Picone and Mithila Burute and Regina Dagher and Ying Su and Cheuk T. Leung and Kornelia Polyak and Joan S. Brugge and Manuel Th{\'e}ry and David Pellman},
  booktitle={Nature},
  year={2014}
}
Centrosome amplification has long been recognized as a feature of human tumours; however, its role in tumorigenesis remains unclear. Centrosome amplification is poorly tolerated by non-transformed cells and, in the absence of selection, extra centrosomes are spontaneously lost. Thus, the high frequency of centrosome amplification, particularly in more aggressive tumours, raises the possibility that extra centrosomes could, in some contexts, confer advantageous characteristics that promote… CONTINUE READING

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