Oncogene jun encodes a sequence-specific trans- activator similar to AP-1

@article{Angel1988OncogeneJE,
  title={Oncogene jun encodes a sequence-specific trans- activator similar to AP-1},
  author={Peter Angel and Elizabeth A. Allegretto and Steve T. Okino and Kazue Hattori and William J. Boyle and Tony Hunter and Michael Karin},
  journal={Nature},
  year={1988},
  volume={332},
  pages={166-171}
}
Proto-oncogenes encode proteins with three main sites of action: the cell-surface membrane, the cytoplasm and the nucleus1,2. Although the exact biochemical function of most proto-oncogene products is not understood, several of them are known to be involved in signal transduction3–7. A role in gene regulation through DNA binding has been suggested for a recently isolated member of the group of oncogenes acting at the nucleus, v-jun. The C-terminus of the putative v-jun-encoded protein is… CONTINUE READING