Oncogene jun encodes a sequence-specific trans- activator similar to AP-1

@article{Angel1988OncogeneJE,
  title={Oncogene jun encodes a sequence-specific trans- activator similar to AP-1},
  author={P. Angel and E. Allegretto and S. Okino and K. Hattori and W. Boyle and T. Hunter and M. Karin},
  journal={Nature},
  year={1988},
  volume={332},
  pages={166-171}
}
  • P. Angel, E. Allegretto, +4 authors M. Karin
  • Published 1988
  • Biology, Medicine
  • Nature
  • Proto-oncogenes encode proteins with three main sites of action: the cell-surface membrane, the cytoplasm and the nucleus1,2. Although the exact biochemical function of most proto-oncogene products is not understood, several of them are known to be involved in signal transduction3–7. A role in gene regulation through DNA binding has been suggested for a recently isolated member of the group of oncogenes acting at the nucleus, v-jun. The C-terminus of the putative v-jun-encoded protein is… CONTINUE READING
    The transactivating domain of the c-Jun proto-oncoprotein is required for cotransformation of rat embryo cells.
    • 134
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    The jun proto-oncogene is positively autoregulated by its product, Jun/AP-1
    • 1,008

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