Oncogene-induced telomere dysfunction enforces cellular senescence in human cancer precursor lesions

  title={Oncogene-induced telomere dysfunction enforces cellular senescence in human cancer precursor lesions},
  author={Anitha Suram and Jessica M. Kaplunov and Priyanka L Patel and Haihe Ruan and Aurora Cerutti and Virginia Boccardi and Marzia Fumagalli and Raffaella Di Micco and Neena M. Mirani and Resham Lal Gurung and Manoor Prakash Hande and Fabrizio d'Adda di Fagagna and Utz Herbig},
  booktitle={The EMBO journal},
In normal human somatic cells, telomere dysfunction causes cellular senescence, a stable proliferative arrest with tumour suppressing properties. Whether telomere dysfunction-induced senescence (TDIS) suppresses cancer growth in humans, however, is unknown. Here, we demonstrate that multiple and distinct human cancer precursor lesions, but not corresponding malignant cancers, are comprised of cells that display hallmarks of TDIS. Furthermore, we demonstrate that oncogenic signalling, frequently… CONTINUE READING
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