Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints

@article{Brtkov2006OncogeneinducedSI,
  title={Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints},
  author={Jiřina B{\'a}rtkov{\'a} and Nousin Rezaei and Michalis Liontos and Panagiotis Karakaidos and Dimitris Kletsas and Natalia Issaeva and Leandros V Vassiliou and Evangelos Kolettas and Katerina Niforou and Vassilis Zoumpourlis and Munenori Takaoka and Hiroshi Nakagawa and Fr{\'e}d{\'e}ric Tort and Kasper Fugger and Fredrik I Johansson and Maxwell Sehested and Claus Lindbjerg Andersen and Lars Dyrskj{\o}t and Torben F. {\O}rntoft and Jiri Lukas and Christos N. Kittas and Thomas Helleday and Thanos D Halazonetis and Jiri Bartek and Vassilis G. Gorgoulis},
  journal={Nature},
  year={2006},
  volume={444},
  pages={633-637}
}
Recent studies have indicated the existence of tumorigenesis barriers that slow or inhibit the progression of preneoplastic lesions to neoplasia. One such barrier involves DNA replication stress, which leads to activation of the DNA damage checkpoint and thereby to apoptosis or cell cycle arrest, whereas a second barrier is mediated by oncogene-induced senescence. The relationship between these two barriers, if any, has not been elucidated. Here we show that oncogene-induced senescence is… Expand
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  • Seminars in cancer biology
  • 2011
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