Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints

  title={Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints},
  author={J. B{\'a}rtkov{\'a} and Nousin Rezaei and M. Liontos and Panagiotis Karakaidos and D. Kletsas and N. Issaeva and Leandros-Vassilios F. Vassiliou and E. Kolettas and K. Niforou and V. Zoumpourlis and M. Takaoka and H. Nakagawa and F. Tort and Kasper Fugger and F. Johansson and M. Sehested and Claus L. Andersen and L. Dyrskj{\o}t and T. {\O}rntoft and J. Lukas and C. Kittas and T. Helleday and Thanos D. Halazonetis and J. Bartek and V. Gorgoulis},
  • J. Bártková, Nousin Rezaei, +22 authors V. Gorgoulis
  • Published 2006
  • Biology, Medicine
  • Nature
  • Recent studies have indicated the existence of tumorigenesis barriers that slow or inhibit the progression of preneoplastic lesions to neoplasia. One such barrier involves DNA replication stress, which leads to activation of the DNA damage checkpoint and thereby to apoptosis or cell cycle arrest, whereas a second barrier is mediated by oncogene-induced senescence. The relationship between these two barriers, if any, has not been elucidated. Here we show that oncogene-induced senescence is… CONTINUE READING
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