Oncogene-induced senescence distinguishes indolent from aggressive forms of pulmonary and non-pulmonary Langerhans cell histiocytosis.

Abstract

The clonal/neoplastic nature of Langerhans cell histiocytosis (LCH) has recently been demonstrated by a high prevalence of BRAF mutations, including pulmonary LCH (PLCH). We hypothesized that BRAF-induced senescence, as demonstrated in nevi and melanoma, is involved in the pathogenesis of LCH and PLCH. In a series of pulmonary (19 cases) and non-pulmonary… (More)
DOI: 10.3109/10428194.2014.887713

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@article{Chilosi2014OncogeneinducedSD, title={Oncogene-induced senescence distinguishes indolent from aggressive forms of pulmonary and non-pulmonary Langerhans cell histiocytosis.}, author={Marco Chilosi and Fabio F. Facchetti and Anna Cali{\`o} and Alberto Zam{\`o} and Matteo Brunelli and Guido Martignoni and Andrea Petronio Rossi and Licia Montagna and Paola Piccoli and Alessandra Dubini and Andrea Tironi and Sara Tomassetti and Venerino Poletti and Claudio Doglioni}, journal={Leukemia & lymphoma}, year={2014}, volume={55 11}, pages={2620-6} }