Oncogene-induced basement membrane invasiveness in human mammary epithelial cells

  title={Oncogene-induced basement membrane invasiveness in human mammary epithelial cells},
  author={Erik W Thompson and Jeffrey A. Torri and Marybeth Sabol and Connie L. Sommers and Stephen J Byers and Eva M. Valverius and George Robert Martin and Marc E. Lippman and Martha R. Stampfer and Robert B. Dickson},
  journal={Clinical & Experimental Metastasis},
Expression of the intermediate filament protein vimentin, and loss of the cellular adhesion protein uvomorulin (E-cadherin) have been associated with increased invasiveness of established human breast cancer cell linesin vitro andin vivo. In the current study, we have further examined these relationships in oncogenically transformed human mammary epithelial cells. A normal human mammary epithelial strain, termed 184, was previously immortalized with benzo[a]pyrene, and two distinct sublines… CONTINUE READING


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