Oncogene and cytokine expression of human colorectal tumors responding to immunotherapy.

@article{Doran1997OncogeneAC,
  title={Oncogene and cytokine expression of human colorectal tumors responding to immunotherapy.},
  author={Teri Doran and H Stuhlmiller and Julian A. Kim and E. W. Martin and Pierre L Triozzi},
  journal={Journal of immunotherapy},
  year={1997},
  volume={20 5},
  pages={372-6}
}
Tumor samples from five patients with metastatic colorectal cancer who demonstrated tumor regressions in clinical trials of interleukin (IL)-1 beta, IL-2, and adoptive cellular therapy were analyzed for oncogene and cytokine mRNA expression. Tumors from eight nonresponding patients were also studied. Mutations of the ras protooncogene and overexpression of c-myc protooncogene were observed in both responding and nonresponding tumors. In contrast, none of the responding tumors expressed… CONTINUE READING