Oncogene amplification in breast cancer.

  title={Oncogene amplification in breast cancer.},
  author={Maryann Donovan-Peluso and Alessandro Contento and Hector Tobon and B Ripepi and J. Locker},
  journal={The American journal of pathology},
  volume={138 4},
To refine the analysis of gene amplification in breast cancer, the authors have developed sensitive methods that can be used to screen nucleic acid prepared from a variety of sources. In their analysis, Southern hybridization and DNA dot-blot analysis were used to screen 49 breast cancer DNAs for Myc, Neu, and Int-2 gene amplification. The analysis detected minimal one extra gene copy) as well as expanded (two or more extra gene copies) gene amplifications, and in addition, distinguished… CONTINUE READING