Oncogene activation and tumor suppressor gene inactivation during multistage mouse skin carcinogenesis.

@article{Bowden1994OncogeneAA,
  title={Oncogene activation and tumor suppressor gene inactivation during multistage mouse skin carcinogenesis.},
  author={G T Bowden and B Schneider and R Domann and Molly Kulesz-Martin},
  journal={Cancer research},
  year={1994},
  volume={54 7 Suppl},
  pages={1882s-1885s}
}
The mouse skin multistage model of carcinogenesis is an ideal system in which to study questions related to the timing of oncogene activation and inactivation of tumor suppressor genes. A number of laboratories have shown that an early event associated with chemical initiation of mouse skin tumors involves activation of the Harvey-ras oncogene. To approach the question of timing of loss of tumor suppressor genes in skin carcinogenesis, we have utilized a model system developed by Kulesz-Martin… CONTINUE READING
14 Extracted Citations
40 Extracted References
Similar Papers

Citing Papers

Publications influenced by this paper.
Showing 1-10 of 14 extracted citations

Referenced Papers

Publications referenced by this paper.
Showing 1-10 of 40 references

Dominant negative myr blocks Iransformalion by ABL oncogcnes

  • A. Lloyd., H. Yancheva, B Waszlyk.
  • Cell .
  • 1992

Altered expression of wild - type p 53 tumor suppressor gene during murine epithelial cell Iransformation

  • Han. K-A., M. F. Kulesz-Martin
  • Oncogene
  • 1991

Inhibition iti jun transformation by a mutated / av gene : design of an anli - oncogene

  • W. Sawyers.C.L..Callahan., H. Witte.O.
  • Oncogene .
  • 1991

The transactivation domain of the c - jun proto - oncogene is required lor cotransformation of rat embryo cells

  • H. Alani. R.. Brown. P.. Binetruy. B.. Dosaka, M. Rosenberg.R.K..Angel.P..Karin., J. Birrer.M.
  • 1991

Alterations of the p 53 tumor suppressor gene during mouse skin tumor progression

  • B. Ruggeri, J.. Goodrow. T. Caamano, A. DiRado.M..Bianchi., D.. Conti. C. J. Trono, A. J. P. Klein-Szanto
  • Proc . Nati . Acad . Sci . USA
  • 1990

Similar Papers

Loading similar papers…