Onco-proteogenomic exploration of variant peptide detection in disease models and clinical specimens

@inproceedings{Dimitrakopoulos2017OncoproteogenomicEO,
  title={Onco-proteogenomic exploration of variant peptide detection in disease models and clinical specimens},
  author={Lampros Dimitrakopoulos},
  year={2017}
}
This thesis describes the efforts of integrating nucleotide sequencing results with mass spectrometry-based proteomic results to identify variants predicted from sequencing and being expressed at the proteome level within a proteogenomic framework. Specifically, the study was carried out in three levels. The first was a proof of concept study to demonstrate the feasibility of variant peptide detection in clinical specimens and reveal intrinsic strengths and weaknesses of the onco-proteogenomic… CONTINUE READING

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