Onchocerca volvulus-mediated keratitis: cytokine production by IL-4-deficient mice.

Abstract

Corneal inflammation similar to human onchocercal keratitis can be induced in mice by subcutaneous immunization of a soluble extract of Onchocerca volvulus (OvAg) followed by direct injection of OvAg into the corneal stroma. Previous studies have shown that corneal pathology is associated with increased systemic and corneal Th2 cytokine expression and that… (More)

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Cite this paper

@article{Pearlman1996OnchocercaVK, title={Onchocerca volvulus-mediated keratitis: cytokine production by IL-4-deficient mice.}, author={Eric Pearlman and Jonathan H. Lass and David S Bardenstein and Eugenia Diaconu and Fred E Hazlett and Jay C. Albright and Anne W. Higgins and James W. Kazura}, journal={Experimental parasitology}, year={1996}, volume={84 2}, pages={274-81} }