Once versus twice daily gentamicin dosing for infective endocarditis: a randomized clinical trial.

OBJECTIVES The aim of this randomized study was to investigate the effects of once versus twice daily gentamicin dosing on renal function and measures of infectious disease in a population with infective endocarditis (IE). METHODS Seventy-one IE patients needing gentamicin treatment according to guidelines were randomized to either once (n = 37) or twice… CONTINUE READING