Once versus thrice daily gentamicin in patients with serious infections

@article{Prins1993OnceVT,
  title={Once versus thrice daily gentamicin in patients with serious infections},
  author={Jan C M Prins and HarryR. B{\"u}ller and Edward J. Kuijper and Rinze Anthony Tange and Peter Speelman},
  journal={The Lancet},
  year={1993},
  volume={341},
  pages={335-339}
}
Aminoglycosides are usually given in two or three divided doses. A once-daily regimen might be more effective and less toxic. We have conducted a randomised trial in consecutive patients with serious infections for whom an aminoglycoside seemed warranted. Exclusion criteria were neutropenia or severely impaired renal function. 123 patients were enrolled. For efficacy analysis only those patients were considered in whom treatment with the aminoglycoside was not stopped within 72 h (n = 67… CONTINUE READING
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