Once upon a time, inflammation

  title={Once upon a time, inflammation},
  author={Jean-Marc Cavaillon},
  journal={The Journal of Venomous Animals and Toxins Including Tropical Diseases},
  • J. Cavaillon
  • Published 9 April 2021
  • Biology
  • The Journal of Venomous Animals and Toxins Including Tropical Diseases
Abstract Inflammation has accompanied humans since their first ancestors appeared on Earth. Aulus Cornelius Celsus (25 BC-50 AD), a Roman encyclopedist, offered a still valid statement about inflammation: “Notae vero inflammationis sunt quatuor: rubor et tumor cum calore and dolore”, defining the four cardinal signs of inflammation as redness and swelling with heat and pain. While inflammation has long been considered as a morbid phenomenon, John Hunter (18th century) and Elie Metchnikoff (19th… 

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