Once-only flexible sigmoidoscopy screening in prevention of colorectal cancer: a multicentre randomised controlled trial

  title={Once-only flexible sigmoidoscopy screening in prevention of colorectal cancer: a multicentre randomised controlled trial},
  author={W. Atkin and R. Edwards and I. Kralj-Hans and K. Wooldrage and A. Hart and J. Northover and D. Parkin and J. Wardle and S. Duffy and J. Cuzick},
  journal={The Lancet},
  • W. Atkin, R. Edwards, +7 authors J. Cuzick
  • Published 2010
  • Medicine
  • The Lancet
  • BACKGROUND Colorectal cancer is the third most common cancer worldwide and has a high mortality rate. We tested the hypothesis that only one flexible sigmoidoscopy screening between 55 and 64 years of age can substantially reduce colorectal cancer incidence and mortality. METHODS This randomised controlled trial was undertaken in 14 UK centres. 170 432 eligible men and women, who had indicated on a previous questionnaire that they would accept an invitation for screening, were randomly… CONTINUE READING
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