Once-only flexible sigmoidoscopy screening in prevention of colorectal cancer: a multicentre randomised controlled trial

@article{Atkin2010OnceonlyFS,
  title={Once-only flexible sigmoidoscopy screening in prevention of colorectal cancer: a multicentre randomised controlled trial},
  author={Wendy S. Atkin and Robert A. Edwards and Ines Kralj-Hans and Kate Wooldrage and Andrew R Hart and John M. A. Northover and David Parkin and Jane Wardle and Stephen W. Duffy and Jack M Cuzick},
  journal={The Lancet},
  year={2010},
  volume={375},
  pages={1624-1633}
}
BACKGROUND Colorectal cancer is the third most common cancer worldwide and has a high mortality rate. We tested the hypothesis that only one flexible sigmoidoscopy screening between 55 and 64 years of age can substantially reduce colorectal cancer incidence and mortality. METHODS This randomised controlled trial was undertaken in 14 UK centres. 170 432 eligible men and women, who had indicated on a previous questionnaire that they would accept an invitation for screening, were randomly… Expand
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Once-only flexible sigmoidoscopy screening in prevention of colorectal cancer: a multicentre randomised controlled trial
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Once-only sigmoidoscopy in colorectal cancer screening: follow-up findings of the Italian Randomized Controlled Trial--SCORE.
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A single flexible sigmoidoscopy screening between ages 55 and 64 years was associated with a substantial reduction of CRC incidence and mortality. Expand
Effect of flexible sigmoidoscopy screening on colorectal cancer incidence and mortality: a randomized clinical trial.
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In Norway, once-only flexible sigmoidoscopy screening or flexible sigmatoscopy and FOBT reduced colorectal cancer incidence and mortality on a population level compared with no screening. Expand
Effectiveness of flexible sigmoidoscopy screening in men and women and different age groups: pooled analysis of randomised trials
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Flexible sigmoidoscopy is an effective tool for colorectal cancer screening in men and younger women but the benefit is smaller and not statistically significant for women aged over 60; alternative screening methods that more effectively detect proximal tumours should be considered for these women. Expand
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The effects of screening seemed to be robust enough not to be strongly affected by differences across the trials in CRC prevalence, willingness to be screened, threshold for follow-up colonoscopy, and unplanned screening among controls. Expand
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A single flexible sigmoidoscopy continues to provide substantial protection from colorectal cancer diagnosis and death, with protection lasting at least 17 years. Expand
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There is high quality evidence that both flexible sigmoidoscopy and faecal occult blood testing reduce colorectal cancer mortality when applied as screening tools and low quality indirect evidence that screening with either approach reduces coloreCTal cancer deaths more than the other. Expand
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Results of a large randomized trial of colorectal cancer screening in Norway in which one-time flexible sigmoidoscopy was compared with no screening maintain that sigmoidsoscopy and FOBT are still appropriate initial screening options. Expand
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The findings of Atkin and colleagues’ extended followup should inform future modelling efforts and lead to a better understanding of the natural history of adenoma, as well as provide needed data from a public health perspective on the optimal design of a screening programme that incorporates flexible sigmoidoscopy. Expand
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Screening with flexible sigmoidoscopy was associated with a significant decrease in colorectal-cancer incidence (in both the distal and proximal colon) and mortality (distal colon only). Expand
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This first randomized trial on the long-term effect of endoscopic screening shows reduced CRC incidence and mortality if screening is combined with rigorous surveillance for individuals with polyps, and Colonoscopy screening without such surveillance may not be effective. Expand
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