Once-daily versus multiple-daily dosing of aminoglycosides.

  title={Once-daily versus multiple-daily dosing of aminoglycosides.},
  author={William A P Craig},
  journal={Journal of chemotherapy},
  volume={7 Suppl 2},
The pharmacodynamic characteristics of isepamicin and other aminoglycosides, both in terms of efficacy and toxicity, explain why once-daily administration of these agents should be the optimal dosing regimen. Isepamicin, as with other aminoglycosides, exhibits concentration-dependent bactericidal activity and produces prolonged post-antibiotic effects against susceptible organisms. High concentrations of these drugs would be expected to produce more rapid and extensive bacterial killing than… CONTINUE READING

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