Once-daily tobramycin in cystic fibrosis: better for clinical outcome than thrice-daily tobramycin but more resistance development?

@article{Burkhardt2006OncedailyTI,
  title={Once-daily tobramycin in cystic fibrosis: better for clinical outcome than thrice-daily tobramycin but more resistance development?},
  author={Olaf Burkhardt and Christine Lehmann and Rajanikanth Madabushi and Vipul Kumar and Hartmut Derendorf and Tobias Welte},
  journal={The Journal of antimicrobial chemotherapy},
  year={2006},
  volume={58 4},
  pages={822-9}
}
OBJECTIVES Once-daily administration of aminoglycosides in cystic fibrosis (CF) patients is considered equally efficacious and potentially less nephrotoxic than dosing three times a day. However, the choice of the most suitable PK/PD index (C(max)/MIC versus AUC(24)/MIC) to ensure optimum clinical outcome in this patient population is not clear. PATIENTS AND METHODS In a single-centre, open, randomized, controlled, non-blinded study 33 adult CF patients (20 females, 19-37 years) were treated… CONTINUE READING
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