Once-daily propranolol extended-release tablet dosage form: formulation design and in vitro/in vivo investigation.

Abstract

The purpose of this study was to develop and optimize the propranolol once-daily extended release formulations containing HPMC, Microcrystalline cellulose (MCC) and lactose. In vitro studies, the response surface methodology and multiple response optimization utilizing the polynomial equation were used to search for the optimal formulation with specific… (More)

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