Once-daily indacaterol versus tiotropium for patients with severe chronic obstructive pulmonary disease (INVIGORATE): a randomised, blinded, parallel-group study.

@article{Decramer2013OncedailyIV,
  title={Once-daily indacaterol versus tiotropium for patients with severe chronic obstructive pulmonary disease (INVIGORATE): a randomised, blinded, parallel-group study.},
  author={Marc Decramer and Kenneth R Chapman and Ronald Dahl and Peter A Frith and Gilles Devouassoux and Carlos Cezar Fritscher and Ray Cameron and Muhammad Shoaib and David S Lawrence and David Z. Young and Danny McBryan},
  journal={The Lancet. Respiratory medicine},
  year={2013},
  volume={1 7},
  pages={524-33}
}
BACKGROUND We compared the efficacy and safety of indacaterol and tiotropium in patients with severe chronic obstructive pulmonary disease (COPD) and a history of at least one moderate to severe exacerbation in the previous 12 months. METHODS In this multicentre, randomised, blinded, double-dummy, parallel group study, we enrolled patients aged 40 years or older with severe COPD and at least one exacerbation within the previous year. We used a computer-generated sequence to randomly allocate… CONTINUE READING
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