Once-daily dosing of aminoglycosides

  title={Once-daily dosing of aminoglycosides},
  author={J{\"u}rg Blaser and C. -H. Wirsing von K{\"o}nig},
  journal={European Journal of Clinical Microbiology and Infectious Diseases},
Since their introduction one or more decades ago, aminoglycosides have generally been administered in multiple daily (i.e. twiceor thrice-daily) dosing regimens. However, nephrotoxicity can be reduced in animal models by administering the same total daily dose as one large dose instead of as multiple small doses. In addition, in vitro and in vivo studies that considered the impact of dosing regimens on efficacy suggest that once-daily dosing is equally or more effective compared to multiple… CONTINUE READING

From This Paper

Figures, tables, and topics from this paper.


Publications citing this paper.
Showing 1-10 of 14 extracted citations

Once-daily gentamicin therapy for experimental Escherichia coli meningitis.

Antimicrobial agents and chemotherapy • 1997
View 5 Excerpts
Highly Influenced

Infektiöse Endokarditis

Herz Kardiovaskuläre Erkrankungen • 2006
View 1 Excerpt

Treatment of plague with gentamicin or doxycycline in a randomized clinical trial in Tanzania.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America • 2006
View 1 Excerpt

Pharmacodynamics and dosing of aminoglycosides.

Infectious disease clinics of North America • 2003
View 1 Excerpt

Once-daily aminoglycosides in patients with neutropenic fever.

Cancer control : journal of the Moffitt Cancer Center • 2002


Publications referenced by this paper.
Showing 1-10 of 81 references

Cometta A, Glauser M, members of the IATCG-EORTC: Multicenter quality control study of amikacin assay for monitoring once-daily dosing regimens

J Blaser, C K6nig, R Fatio, F Follath
Therapeutic Drug Monitoring • 1995

A comparative trial of single versus triple dose of aminoglycosides in patients with cystic fibrosis and pulmonary exacerbation

U Heininger, B BSwing, K Stehr, W Soibach
Klinische P~tdiatrie • 1993

Similar Papers

Loading similar papers…