Once-daily dosing of aminoglycosides

@article{Blaser1995OncedailyDO,
  title={Once-daily dosing of aminoglycosides},
  author={J{\"u}rg Blaser and C. -H. Wirsing von K{\"o}nig},
  journal={European Journal of Clinical Microbiology and Infectious Diseases},
  year={1995},
  volume={14},
  pages={1029-1038}
}
Since their introduction one or more decades ago, aminoglycosides have generally been administered in multiple daily (i.e. twiceor thrice-daily) dosing regimens. However, nephrotoxicity can be reduced in animal models by administering the same total daily dose as one large dose instead of as multiple small doses. In addition, in vitro and in vivo studies that considered the impact of dosing regimens on efficacy suggest that once-daily dosing is equally or more effective compared to multiple… CONTINUE READING

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