Once-daily dosing of aminoglycoside antibiotics.

  title={Once-daily dosing of aminoglycoside antibiotics.},
  author={David N. Fisman and Kenneth M Kaye},
  journal={Infectious disease clinics of North America},
  volume={14 2},
Improved understanding of the pharmacodynamics and toxicity of aminoglycoside antibiotics has resulted in the study of once-daily dosing regimens. Although studies have suggested a therapeutic advantage and possibly a decrease in toxicity with once-daily administration, these effects have been modest. The cost savings associated with once-daily aminoglycoside administration, however, makes this approach appealing. Although a syndrome of fever, tachycardia, hypotension, and rigors has been… CONTINUE READING