Once-daily controlled release remoxipride is equieffective with twice-daily immediate release remoxipride in the treatment of schizophrenia

@article{Alexander1993OncedailyCR,
  title={Once-daily controlled release remoxipride is equieffective with twice-daily immediate release remoxipride in the treatment of schizophrenia},
  author={M S Alexander and Seema Chakravarti and Kripa Sundararajan and J M Mullin and S H Shaw and M. Blomqvist and C M Lockett},
  journal={Journal of Psychopharmacology},
  year={1993},
  volume={7},
  pages={276 - 282}
}
A controlled release (CR) formulation of remoxipride (Roxiam®, Astra) given once-daily was compared to immediate release (IR) remoxipride given twice-daily, with respect to efficacy and tolerability, in a 4-week multicentre parallel-group dose titration (200-600 mg/day) study with acutely ill schizophrenic patients. Forty- three patients received remoxipride CR (mean dose 344 mg/day) and 49 patients received remoxipride IR (mean dose 346 mg/day). Efficacy was assessed using the Kolakowska… 

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