Once daily aminoglycoside therapy. Is it less toxic than multiple daily doses and how should it be monitored?

@article{Barclay1999OnceDA,
  title={Once daily aminoglycoside therapy. Is it less toxic than multiple daily doses and how should it be monitored?},
  author={Murray Lindsay Barclay and Carl M. J. Kirkpatrick and Evan James Begg},
  journal={Clinical pharmacokinetics},
  year={1999},
  volume={36 2},
  pages={89-98}
}
After 50 years of clinical experience with the aminoglycoside agents, there is continuing debate over the most appropriate administration regimen for these drugs. In recent years, once daily administration has been used increasingly, in the hope of both improving efficacy and reducing toxicity. At least 30 controlled clinical trials have compared once versus conventional multiple daily administration. Efficacy was assessed in some, but not all, studies using clinical and/or bacteriological cure… CONTINUE READING
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