Once-daily aminoglycoside therapy.

  title={Once-daily aminoglycoside therapy.},
  author={David N. Gilbert},
  journal={Antimicrobial agents and chemotherapy},
  volume={35 3},
The once-daily administration of aminoglycosides is an attractive concept. In animal experiments and clinical trials, there is either a reduction in or no influence on the risk of toxicity. Less frequent dosing reduces the contact time between host tissue binding sites and drug. Thanks to the PAE and perhaps other as-yet-unrecognized factors, the fall in the level in serum below the MIC does not appear to impair antibacterial efficacy; in fact, the higher peak level in serum may enhance drug… CONTINUE READING