Once-daily LCP-Tacro MeltDose tacrolimus for the prophylaxis of organ rejection in kidney and liver transplantations.

@article{Grinyo2014OncedailyLM,
  title={Once-daily LCP-Tacro MeltDose tacrolimus for the prophylaxis of organ rejection in kidney and liver transplantations.},
  author={Josep Mar{\'i}a Grinyo and Stefano Petruzzelli},
  journal={Expert review of clinical immunology},
  year={2014},
  volume={10 12},
  pages={1567-79}
}
Tacrolimus is a cornerstone of the immunosuppression regimen for prevention of allograft rejection in kidney and liver transplantations, with efficacy proven in many clinical trials. The currently available and extensively used tacrolimus formulations are flawed by large inter- and intra-individual variability, low bioavailability, wide peak-to-trough fluctuations and a narrow therapeutic index. Drug delivery technology can significantly impact the pharmacologic action of a drug, influencing… CONTINUE READING