• Chemistry, Medicine
  • Published in
    Journal of pharmaceutical…
    2005
  • DOI:10.1002/jps.20387

Once-a-day extended-release dosage form of divalproex sodium III: development and validation of a Level A in vitro-in vivo correlation (IVIVC).

@article{Dutta2005OnceadayED,
  title={Once-a-day extended-release dosage form of divalproex sodium III: development and validation of a Level A in vitro-in vivo correlation (IVIVC).},
  author={Sandeep Dutta and Yihong Qiu and Emil Samara and Guoliang Cao and George Richard Granneman},
  journal={Journal of pharmaceutical sciences},
  year={2005},
  volume={94 9},
  pages={
          1949-56
        }
}
Defining a quantitative and reliable relationship between in vitro drug release and in vivo absorption is highly desired for rational development, optimization, and evaluation of controlled-release dosage forms and manufacturing process. During the development of a once-daily extended-release (ER) tablet of divalproex sodium, a predictive in vitro drug release method was designed and statistically evaluated using three formulations with varying release rates. In order to establish an internally… CONTINUE READING

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