Once-Daily High-Dose Pindolol for Paroxetine-Refractory Premature Ejaculation: A Double-Blind, Placebo-Controlled and Randomized Study

  title={Once-Daily High-Dose Pindolol for Paroxetine-Refractory Premature Ejaculation: A Double-Blind, Placebo-Controlled and Randomized Study},
  author={Mohammad Reza Safarinejad},
  journal={Journal of Clinical Psychopharmacology},
  • M. Safarinejad
  • Published 1 February 2008
  • Medicine
  • Journal of Clinical Psychopharmacology
Purpose: To evaluate the efficacy and safety of pindolol 7.5 mg/d in delaying of ejaculation in paroxetine-refractory patients. Materials and Methods: Eighty-six married men (mean age, 33 years) with premature ejaculation unresponsive to paroxetine 20 mg/d given for 2 months or longer were randomized to receive 7.5 mg pindolol (n = 44) (group 1) (PXT + POL) or placebo (n = 42) (group 2) (PXT + PBO) for 6 weeks, while continuing paroxetine. After 6 weeks, all patients received paroxetine and… 

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