Once-Daily Cefazolin and Probenecid for Skin and Soft Tissue Infections

  title={Once-Daily Cefazolin and Probenecid for Skin and Soft Tissue Infections},
  author={Victoria C Cox and Peter J. Zed},
  journal={Annals of Pharmacotherapy},
  pages={458 - 463}
OBJECTIVE To review the pharmacokinetic and clinical evidence for the use of once-daily cefazolin and probenecid in the treatment of skin and soft tissue infections (SSTI). DATA SOURCES MEDLINE (1966–July 2003), EMBASE (1980–July 2003), and PubMed (1966–July 2003) databases for English language, human reports were searched. Search terms included cefazolin, probenecid, cellulitis, and soft tissue infections. STUDY SELECTION AND DATA EXTRACTION Studies that described pharmacokinetic and clinical… 

Risk Factors of Cellulitis Treatment Failure with Once-Daily Intravenous Cefazolin Plus Oral Probenecid

Patients with cellulitis and CVD who are being treated with once-daily intravenous cefazolin plus probenecid should be monitored closely for treatment failure.

Treatment Options for Gram-Positive and Gram-Negative Bacteria: Focus on Ceftriaxone

Ceftriaxone is a third-generation of cephalosporins which is used for community acquired infections such as pneumonia and urinaly tract infections and used for Sexually Transmited Disease (STD) such as syphilis and chancoroid.

Simultaneous Determination of Cefalexin, Cefazolin, Flucloxacillin, and Probenecid by Liquid Chromatography–Tandem Mass Spectrometry for Total and Unbound Concentrations in Human Plasma

A liquid chromatography–tandem mass spectrometry method for the simultaneous determination of total and unbound concentrations of 3 widely used &bgr;-lactam antibiotics and the often coadministered drug probenecid in human plasma is developed and validated.

Antibiotics in the clinical pipeline in October 2019

There is still a significant gap in the pipeline for the development of new antibacterials with activity against β-metallolactamases, orally administered with broad spectrum G−ve activity, and new treatments for MDR Acinetobacter and gonorrhea.

The Management of Outpatient Cellulitis at The Moncton Hospital before and after the Initiation of a Clinical Treatment Pathway

The introduction of a clinical order set outlining the preferential use of once-daily cefazolin plus probenecid for the treatment of outpatient cellulitis lead to a statistically significant increase use of cefzolin, and decrease use of ceftriaxone, thus demonstrating a positive stewardship effect at a local level.

Management of Cellulitis in a Pediatric Emergency Department

Noncomplicated, nonfacial cellulitis is most commonly treated using first-generation cephalosporins and twice-daily cefazolin and probenecid was associated with less treatment failures and admissions than cefzolin alone and may represent a reasonable alternative for children with nonf facial cellulitis requiring intravenous antibiotics.


Antibiotic prophylaxis with intramuscular penicillin is effective and safe method to reduce the number and frequency of recurrences in patients with known underlying risk factors.

Treatment failure in emergency department patients with cellulitis.

The treatment of cellulitis with daily emergency department-based intravenous antibiotics has a failure rate of more than 25% in the authors' centre, and cellulitis patients with a larger surface area of infection and previous (failed) oral therapy are more likely to fail treatment.

A cellulitis guideline at a community hospital - we can reduce costs by standardizing care.

Patients treated in accordance with the cellulitis guideline had similar outcomes to those treated otherwise, at significantly lower cost.



Teicoplanin for skin and soft tissue infections: An open study and a randomized, comparative trial versus cefazolin

  • D. Stevens
  • Medicine, Biology
    Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy
  • 1999
Once-daily dosing with teicoplanin may allow physicians to treat skin and soft tissue infections on a totally outpatient basis and show similar overall efficacy to cefazolin.

Effect of Chronic Probenecid Therapy on Cefazolin Serum Concentrations

Probenecid 500 mg given orally 4 times daily was effective in maintaining therapeutic serum concentrations of cefazolin at steady-state when given with intravenous cefzolin 2000 mg once daily.

Ceftriaxone treatment of skin and soft tissue infections in a once daily regimen.

Ceftriaxone appears to be an effective agent when given once daily as therapy for many serious skin and soft tissue infections.

Randomized Comparison Trial of Teicoplanin IV, Teicoplanin IM, and Cefazolin Therapy for Skin and Soft Tissue Infections Caused by Gram‐Positive Bacteria

Once daily teicoplanin appeared to be safe and effective therapy for skin and soft tissue infections caused by gram-positive bacteria.

Cephalosporin-Probenecid Drug Interactions

The therapeutic efficacy of a combination of a cephalosporin with probenecid has been most thoroughly studied for single-dose treatment of gonorrhoea and the success of ceftriaxone administered alone for treatment of both penicillase-producing and non-penicillases-producing strains of N. gonor rhoeae suggests that the addition of probenECid is unnecessary.

Clinical Pharmacokinetics of Probenecid

There are 2 primary clinical uses for probenecid: as a uricosuric agent in the treatment of chronic gout and as an adjunct to enhance blood levels of antibiotics (such as penicillins and Cephalosporins).

Treatment of gonorrhea with cefazolin plus probenecid.

  • W. C. Duncan
  • Medicine, Biology
    The Journal of infectious diseases
  • 1974
A new parenteral cephalosporin C derivative, cefazolin, was examined alone and with probenecid, and the two regimens were compared with aqueous procaine penicillin G plus probenacid in the treatment of uncomplicated gonorrhea.

Once-daily ceftriaxone for skin and soft tissue infections

Ceftriaxone given as a single daily intramuscular injection is effective therapy for skin and soft tissue infections.

Once-daily intravenous cefazolin plus oral probenecid is equivalent to once-daily intravenous ceftriaxone plus oral placebo for the treatment of moderate-to-severe cellulitis in adults.

  • M. GraysonM. McDonald Fran Chambers
  • Medicine, Biology
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
  • 2002
The once-daily regimen of cefazolin-probenecid is a cheap, practical, and effective treatment option for moderate-to-severe cellulitis, and it avoids the need to use third-generation cephalosporins in most patients.