Once-Daily Cefazolin and Probenecid for Skin and Soft Tissue Infections

@article{Cox2004OnceDailyCA,
  title={Once-Daily Cefazolin and Probenecid for Skin and Soft Tissue Infections},
  author={Victoria C Cox and Peter J. Zed},
  journal={Annals of Pharmacotherapy},
  year={2004},
  volume={38},
  pages={458 - 463}
}
OBJECTIVE To review the pharmacokinetic and clinical evidence for the use of once-daily cefazolin and probenecid in the treatment of skin and soft tissue infections (SSTI). DATA SOURCES MEDLINE (1966–July 2003), EMBASE (1980–July 2003), and PubMed (1966–July 2003) databases for English language, human reports were searched. Search terms included cefazolin, probenecid, cellulitis, and soft tissue infections. STUDY SELECTION AND DATA EXTRACTION Studies that described pharmacokinetic and clinical… 
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There is the potential for significant cost savings in utilizing outpatient cefazolin therapy over ceftriaxone for treatment of these infections and the outcome, as determined by the ratio of the involved infected area on initial and last treatment day, and the frequency of failure were similar.
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Once-daily dosing with teicoplanin may allow physicians to treat skin and soft tissue infections on a totally outpatient basis and show similar overall efficacy to cefazolin.
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