Once-Daily Cefazolin and Probenecid for Skin and Soft Tissue Infections
@article{Cox2004OnceDailyCA, title={Once-Daily Cefazolin and Probenecid for Skin and Soft Tissue Infections}, author={Victoria C Cox and Peter J. Zed}, journal={Annals of Pharmacotherapy}, year={2004}, volume={38}, pages={458 - 463} }
OBJECTIVE To review the pharmacokinetic and clinical evidence for the use of once-daily cefazolin and probenecid in the treatment of skin and soft tissue infections (SSTI). DATA SOURCES MEDLINE (1966–July 2003), EMBASE (1980–July 2003), and PubMed (1966–July 2003) databases for English language, human reports were searched. Search terms included cefazolin, probenecid, cellulitis, and soft tissue infections. STUDY SELECTION AND DATA EXTRACTION Studies that described pharmacokinetic and clinical…
18 Citations
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The Management of Outpatient Cellulitis at The Moncton Hospital before and after the Initiation of a Clinical Treatment Pathway
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The introduction of a clinical order set outlining the preferential use of once-daily cefazolin plus probenecid for the treatment of outpatient cellulitis lead to a statistically significant increase use of cefzolin, and decrease use of ceftriaxone, thus demonstrating a positive stewardship effect at a local level.
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Acute bacterial skin infections and cellulitis
- Medicine, BiologyCurrent opinion in infectious diseases
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Antibiotic treatment of deep skin infections must be active on streptococci; the choice of a larger spectrum of activity depends on clinical presentation, risk factors and the burden of methicillin-resistant staphylococci in the environment.
Management of Cellulitis in a Pediatric Emergency Department
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Noncomplicated, nonfacial cellulitis is most commonly treated using first-generation cephalosporins and twice-daily cefazolin and probenecid was associated with less treatment failures and admissions than cefzolin alone and may represent a reasonable alternative for children with nonf facial cellulitis requiring intravenous antibiotics.
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