On-tissue protein identification and imaging by MALDI-ion mobility mass spectrometry.

@article{Stauber2010OntissuePI,
  title={On-tissue protein identification and imaging by MALDI-ion mobility mass spectrometry.},
  author={Jonathan Stauber and Luke MacAleese and Julien Franck and Emmanuelle Claude and Marten F. Snel and Başak K{\"u}krer Kaletaş and Ingrid M V D Wiel and Maxence Wisztorski and Isabelle Fournier and Ron M. A. Heeren},
  journal={Journal of the American Society for Mass Spectrometry},
  year={2010},
  volume={21 3},
  pages={338-47}
}
MALDI imaging mass spectrometry (MALDI-IMS) has become a powerful tool for the detection and localization of drugs, proteins, and lipids on-tissue. Nevertheless, this approach can only perform identification of low mass molecules as lipids, pharmaceuticals, and peptides. In this article, a combination of approaches for the detection and imaging of proteins and their identification directly on-tissue is described after tryptic digestion. Enzymatic digestion protocols for different kinds of… CONTINUE READING

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