On-tissue protein identification and imaging by MALDI-ion mobility mass spectrometry.

  title={On-tissue protein identification and imaging by MALDI-ion mobility mass spectrometry.},
  author={Jonathan Stauber and Luke MacAleese and Julien Franck and Emmanuelle Claude and Marten F. Snel and Başak K{\"u}krer Kaletaş and Ingrid M V D Wiel and Maxence Wisztorski and Isabelle Fournier and Ron M. A. Heeren},
  journal={Journal of the American Society for Mass Spectrometry},
  volume={21 3},
MALDI imaging mass spectrometry (MALDI-IMS) has become a powerful tool for the detection and localization of drugs, proteins, and lipids on-tissue. Nevertheless, this approach can only perform identification of low mass molecules as lipids, pharmaceuticals, and peptides. In this article, a combination of approaches for the detection and imaging of proteins and their identification directly on-tissue is described after tryptic digestion. Enzymatic digestion protocols for different kinds of… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 50 extracted citations


Publications referenced by this paper.
Showing 1-10 of 46 references

Matrix-Assisted Ultraviolet Laser Desorption of Nonvolatile Compounds

  • M. Karas, D. Bachmann, U. Bahr, F. Hillenkamp
  • Int. J. Mass Spectrom. Ion Processes
  • 1987
Highly Influential
6 Excerpts

Ion Mobility Imaging Mass Spectrometry: A New Tool for In Situ Identification

  • B.K.K.J. Stauber, I. M. van der Wiel, M. F. Snel, E. Claude, R.M.A. Heeren
  • Proceedings of the 56th ASMS conference;
  • 2008
1 Excerpt

Similar Papers

Loading similar papers…