On the vascular inotropic action of 1,25-(OH)2 vitamin D3.

  title={On the vascular inotropic action of 1,25-(OH)2 vitamin D3.},
  author={Richard D. Bukoski and Hong Xue},
  journal={American journal of hypertension},
  volume={6 5 Pt 1},
Previous work from our laboratory showed that injection of 1,25-(OH)2 vitamin D3 (1,25-vitD) into the rat over a 3-day period increases force generating capacity of subsequently isolated resistance arteries. To better understand the mechanism of this vascular inotropic action, we examined the time course of its development and Ca(2+)-associated mechanism of action. Mesenteric resistance arteries were isolated from 12-week-old male spontaneously hypertensive rats (SHR) 6 and 24 h after a single… CONTINUE READING
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