Corpus ID: 23297840

On the value of large multicenter drug intervention trials.

  title={On the value of large multicenter drug intervention trials.},
  author={P. Dernol and G. H{\"u}bner and T. Weihrauch},
  volume={47 8},
  • P. Dernol, G. Hübner, T. Weihrauch
  • Published 1997
  • Medicine
  • Arzneimittel-Forschung
  • Many large multicenter clinical drug trials are outcome trials with several thousand patients, therefore also called megatrials, numerous of which encompassing the cardiovascular field. Usually designed to test and compare the efficacy of a specific therapy with the major aim being improved outcome at hard end-points, specifically morbidity and mortality, they are representative of typical intervention trials. Considering also the risk of failure, examples of large multicenter therapy trials… CONTINUE READING
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