On the use of the quasi-likelihood method in teratological experiments.

@article{Liang1994OnTU,
  title={On the use of the quasi-likelihood method in teratological experiments.},
  author={K Y Liang and John J. Hanfelt},
  journal={Biometrics},
  year={1994},
  volume={50 3},
  pages={872-80}
}
This paper concerns the impact of litter effects on the inference of dose-response relationships in teratological experiments with binary response. Kupper et al. (1986, Biometrics 42, 85-98) concluded that when intra-litter correlations are dose-dependent, the use of a common intra-litter correlation likelihood based on the beta-binomial distribution could lead to severe bias in estimation of the parameter beta, which characterizes the dose-response relationship. We show here that the problems… CONTINUE READING