On the use of size exclusion chromatography for the resolution of mixed amyloid aggregate distributions: I. equilibrium partition models.

@article{Hall2012OnTU,
  title={On the use of size exclusion chromatography for the resolution of mixed amyloid aggregate distributions: I. equilibrium partition models.},
  author={Damien Hall and Li Huang},
  journal={Analytical biochemistry},
  year={2012},
  volume={426 1},
  pages={69-85}
}
In this study, we investigated the theoretical potential of size exclusion chromatography (SEC) for resolving mixtures of protein aggregates (of various sizes and shapes) produced in the generation of amyloid fibrils. We present our findings in the form of an equilibrium partition model. We first review the general characteristics of SEC and discuss the physicochemical features affecting solute transport and partition. We then develop new methods for estimating the transport and partition… CONTINUE READING
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