On the use of sequence homologies to predict protein structure: identical pentapeptides can have completely different conformations.

@article{Kabsch1984OnTU,
  title={On the use of sequence homologies to predict protein structure: identical pentapeptides can have completely different conformations.},
  author={Wolfgang Kabsch and Christian Sander},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1984},
  volume={81 4},
  pages={1075-8}
}
The search for amino acid sequence homologies can be a powerful tool for predicting protein structure. Discovered sequence homologies are currently used in predicting the function of oncogene proteins. To sharpen this tool, we investigated the structural significance of short sequence homologies by searching proteins of known three-dimensional structure for subsequence identities. In 62 proteins with 10,000 residues, we found that the longest isolated homologies between unrelated proteins are… CONTINUE READING