On the use of resampling tests for evaluating statistical significance of binding-site co-occurrence

@inproceedings{Huen2009OnTU,
  title={On the use of resampling tests for evaluating statistical significance of binding-site co-occurrence},
  author={David S. Huen and Steven Russell},
  booktitle={BMC Bioinformatics},
  year={2009}
}
In eukaryotes, most DNA-binding proteins exert their action as members of large effector complexes. The presence of these complexes are revealed in high-throughput genome-wide assays by the co-occurrence of the binding sites of different complex components. Resampling tests are one route by which the statistical significance of apparent co-occurrence can be assessed. We have investigated two resampling approaches for evaluating the statistical significance of binding-site co-occurrence. The… CONTINUE READING