On the use of nonparametric curves in phase I trials with low toxicity tolerance.

@article{Cheung2002OnTU,
  title={On the use of nonparametric curves in phase I trials with low toxicity tolerance.},
  author={Ying Kuen Ken Cheung},
  journal={Biometrics},
  year={2002},
  volume={58 1},
  pages={237-40}
}
Gasparini and Eisele (2000, Biometrics 56, 609-615) propose a design for phase I clinical trials during which dose allocation is governed by a Bayesian nonparametric estimate of the dose-response curve. The authors also suggest an elicitation algorithm to establish vague priors. However, in situations where a low percentile is targeted, priors thus obtained can lead to undesirable rigidity given certain trial outcomes that can occur with a nonnegligible probability. Interestingly, improvement… CONTINUE READING