On the use of dexamethasone to block the pituitary-interrenal axis in the brown trout, Salmo trutta L.

@article{Pickering1987OnTU,
  title={On the use of dexamethasone to block the pituitary-interrenal axis in the brown trout, Salmo trutta L.},
  author={Alan D. Pickering and Thomas G. Pottinger and John P. Sumpter},
  journal={General and comparative endocrinology},
  year={1987},
  volume={65 3},
  pages={346-53}
}
Oral administration of dexamethasone in a single meal at a dose of 3 micrograms g-1 body wt was sufficient to block the secretion of ACTH and cortisol in brown trout subjected to a handling stress followed by 30 min confinement. This dose, however, also had a marked effect on several of the circulating blood cell types. Lymphocyte and neutrophil counts were reduced in dexamethasone-treated fish whereas erythrocyte counts increased. The value of dexamethasone as a tool for investigating the role… CONTINUE READING

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