On the theoretical limits of detecting cyclic changes in cardiac high-energy phosphates and creatine kinase reaction kinetics using in vivo ³¹P MRS.

@article{Weiss2015OnTT,
  title={On the theoretical limits of detecting cyclic changes in cardiac high-energy phosphates and creatine kinase reaction kinetics using in vivo ³¹P MRS.},
  author={Kilian Weiss and Paul A. Bottomley and Robert G. Weiss},
  journal={NMR in biomedicine},
  year={2015},
  volume={28 6},
  pages={694-705}
}
Adenosine triphosphate (ATP) is absolutely required to fuel normal cyclic contractions of the heart. The creatine kinase (CK) reaction is a major energy reserve reaction that rapidly converts creatine phosphate (PCr) to ATP during the cardiac cycle and at times of stress and ischemia, but is significantly impaired in conditions such as hypertrophy and heart failure. Because the magnitudes of possible in vivo cyclic changes in cardiac high-energy phosphates (HEPs) during the cardiac cycle are… CONTINUE READING
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Effect of temperature on the creatine kinase equilibrium

  • WE Teague, Jr., GP Dobson
  • J. Biol. Chem
  • 1992
Highly Influential
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