On the temperature--pressure free-energy landscape of proteins.

  title={On the temperature--pressure free-energy landscape of proteins.},
  author={Revanur Ravindra and Roland Winter},
  journal={Chemphyschem : a European journal of chemical physics and physical chemistry},
  volume={4 4},
We studied the thermodynamic stability of a small monomeric protein, staphylococcal nuclease (Snase), as a function of both temperature and pressure, and expressed it as a 3D free-energy surface on the p,T-plane using a second-order Taylor expansion of the Gibbs free-energy change delta G upon unfolding. We took advantage of a series of different techniques (small-angle X-ray scattering, Fourier-transform infrared spectroscopy, differential thermal analysis, pressure perturbation calorimetry… CONTINUE READING

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