On the synthesis of serine and homoserine samples asymmetrically labelled with tritium and deuterium in the hydroxymethylene group

Abstract

(1 R) [1-3H,2H1] 3-Phenylpropanol, the key intermediate in the synthesis of (4 R) [4-3H,2H1] D, L-homoserine and of the (4 S)-isomer, is obtained from (1 S) [1-2H1] 3-phenylpropanol and (1 RS) [1-3H] ethanol upon incubation with yeast alcohol dehydrogenase and NAD+; under similar conditions 2-phenylethanol undergoes very small exchange with [1-2H2] ethanol.

DOI: 10.1007/BF01922993

Cite this paper

@article{Fuganti1978OnTS, title={On the synthesis of serine and homoserine samples asymmetrically labelled with tritium and deuterium in the hydroxymethylene group}, author={Claudio Jos{\'e} Fuganti and Daniel Ghiringhelli and Piero Grasselli}, journal={Experientia}, year={1978}, volume={34}, pages={297-298} }