On the symmetry of siblings: automated single-cell tracking to quantify the behavior of hematopoietic stem cells in a biomimetic setup.

@article{Scherf2012OnTS,
  title={On the symmetry of siblings: automated single-cell tracking to quantify the behavior of hematopoietic stem cells in a biomimetic setup.},
  author={Nico Scherf and Katja Franke and Ingmar Glauche and Ina Kurth and Martin Bornhaeuser and Carsten Werner and Tilo Pompe and Ingo Roeder},
  journal={Experimental hematology},
  year={2012},
  volume={40 2},
  pages={119-30.e9}
}
The interplay between hematopoietic stem and progenitor cells (HSPC) and their local microenvironment is a key mechanism for the organization of hematopoiesis. To quantitatively study this process, a time-resolved analysis of cellular dynamics at the single-cell level is an essential prerequisite. One way to generate sufficient amounts of appropriate data is automatic single-cell tracking using time-lapse video microscopy. We describe and apply newly developed computational algorithms that… CONTINUE READING
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