On the structure of polymeric IgM

@article{Davis1988OnTS,
  title={On the structure of polymeric IgM},
  author={A. Davis and K. Roux and M. Shulman},
  journal={European Journal of Immunology},
  year={1988},
  volume={18}
}
The cysteine at position 575 of the immunoglobulin μ heavy chain is thought to provide the only disulfide bonds joining the monomer subunits of mouse polymeric IgM. The importance of this cysteine in the assembly of polymeric IgM was investigated by using site‐directed mutagenesis to produce μ chains with serine at position 575. Thirty percent of the secreted mutant IgM was covalently assembled polymer implying that cysteines other than Cys575 can form inter‐subunit disulfide bonds. The… Expand
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