On the stereochemistry and biosynthesis of lipoxin B.

@article{Serhan1986OnTS,
  title={On the stereochemistry and biosynthesis of lipoxin B.},
  author={Charles N Serhan and Mats H{\'a}mberg and Bengt Samuelsson and Joel Morris and Donn G. Wishka},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1986},
  volume={83 7},
  pages={1983-7}
}
Lipoxin B (LXB) was prepared by incubation of (15S)-15-hydroperoxy-5,8,11-cis-13-trans-icosatetraenoic acid (15-HPETE) with human leukocytes. Comparison with a number of trihydroxyicosatetraenes prepared by total synthesis showed that biologically derived LXB is (5S,14R,15S)-5,14,15-trihydroxy-6,10,12-trans-8-cis-icosatetraenoi c acid. Two isomers of LXB were identified by using an improved isolation procedure. These compounds were shown to be (5S,14R,15S)-5,14,15-trihydroxy-6,8,10,12-trans… CONTINUE READING