On the stereochemical course of palladium-catalyzed cross-coupling of allylic silanolate salts with aromatic bromides.

@article{Denmark2010OnTS,
  title={On the stereochemical course of palladium-catalyzed cross-coupling of allylic silanolate salts with aromatic bromides.},
  author={S. Denmark and N. Werner},
  journal={Journal of the American Chemical Society},
  year={2010},
  volume={132 10},
  pages={
          3612-20
        }
}
  • S. Denmark, N. Werner
  • Published 2010
  • Chemistry, Medicine
  • Journal of the American Chemical Society
  • The stereochemical course of palladium-catalyzed cross-coupling reactions of an enantioenriched, alpha-substituted, allylic silanolate salt with aromatic bromides has been investigated. The allylic silanolate salt was prepared in high geometrical (Z/E, 94:6) and high enantiomeric (94:6 er) purity by a copper-catalyzed S(N)2' reaction of a resolved allylic carbamate. Eight different aromatic bromides underwent cross-coupling with excellent constitutional site-selectivity and excellent… CONTINUE READING
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